Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital

作者：Elena Pita Calandre, Carmen M. Rodriguez-Lopez, A. Blazquez, David A. Cano · 发表于：Acta Neurologica Scandinavica · 年份：1991 · DOI：10.1111/j.1600-0404.1991.tb04691.x · 被引用次数：90 · 研究领域：Pharmacological Effects and Toxicity Studies、Epilepsy research and treatment、Hemoglobinopathies and Related Disorders

Serum lipids, lipoproteins and apolipoproteins A and B were measured in 101 epileptic patients receiving chronic treatment with valproic acid, carbamazepine or phenobarbital and in 75 age- and sex-matched control subjects. In relation to controls, subjects treated with valproic acid showed significantly lower values of total and LDL-cholesterol levels; subjects treated with carbamazepine showed significantly higher values of HDL-cholesterol and apolipoprotein A concentrations and subjects treated with phenobarbital showed significantly higher values of total cholesterol, HDL-cholesterol, apolipoprotein A and apolipoprotein B levels. The total cholesterol/HDL-cholesterol ratio was significantly lower in patients receiving valproic acid or carbamazepine but not in the phenobarbital-treated group. Changes in serum lipids profile did not correlate with drug plasma concentrations nor the duration of the treatment.