Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

作者：Tae Kook Kim, Tom Maniatis · 发表于：Science · 年份：1996 · DOI：10.1126/science.273.5282.1717 · 被引用次数：410 · 研究领域：Cytokine Signaling Pathways and Interactions、interferon and immune responses、Ubiquitin and proteasome pathways

STAT proteins (signal transducers and activators of transcription) are latent cytoplasmic transcription factors that are phosphorylated by Janus kinases in response to cytokines. Phosphorylated STAT proteins translocate to the nucleus, where they transiently turn on specific sets of cytokine-inducible genes. The mechanism that controls the amounts of activated STAT proteins is not understood. STAT1 proteins activated by interferon-gamma treatment in HeLa cells were shown to be stabilized by a proteasome inhibitor and ubiquitinated in vivo. Thus, the amount of activated STAT1 may be negatively regulated by the ubiquitin-proteasome pathway.