The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer

作者：Candice L. Downey, Samantha A Simpkins, James T. White, DL Holliday, J. Louise Jones, Lee B. Jordan, Janina Kulka, Steven Pollock, Sreekumar Sundara Rajan, Helene Hoegsbro Thygesen, AM Hanby, Valerie Speirs · 发表于：British Journal of Cancer · 年份：2014 · DOI：10.1038/bjc.2014.69 · 被引用次数：109 · 研究领域：Male Breast Health Studies、Breast Cancer Treatment Studies、Breast Lesions and Carcinomas

BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas. METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed. RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis. CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.