Crystal Structure of Ganciclovir

作者：Tomoko Kawamura, Noriaki Hirayama · 发表于：X-ray Structure Analysis Online · 年份：2009 · DOI：10.2116/xraystruct.25.51 · 被引用次数：12 · 研究领域：Herpesvirus Infections and Treatments、Cytomegalovirus and herpesvirus research、HIV/AIDS drug development and treatment

The crystal of the title compound, C9H13N5O4, belongs to space group P21 with cell dimensions a = 4.380(2), b = 10.909(4), c = 11.601(4)Å, and β = 99.11(3)°. The final R value is 0.0583. The chain moiety corresponding to the ribose ring in guanosine does not adopt a fully extended conformation. The relative orientation of the purine ring and the ether oxygen atom is similar to that observed in one of the crystallographically independent guanosine molecules in the crystal structure of guanosine dehydrate.