METABOLISM OF ADIPOSE TISSUEIN VITRO:NUTRITIONAL FACTORS AND EFFECT OF INSULIN

作者：SHAUL ITZHAKI, E. Wertheimer · 发表于：Endocrinology · 年份：1957 · DOI：10.1210/endo-61-1-72 · 被引用次数：115 · 研究领域：Adipose Tissue and Metabolism、Metabolism, Diabetes, and Cancer

THE oxygen consumption of adipose tissue was investigated by Mirski (1). More recently Haugaard and Marsh (2) found that addition of insulin in vitro increases the oxygen consumption of retroperitoneal body fat in the presence of glucose, lactate, succinate, pyruvate or acetate. Although the utilization of glucose by muscle (rat diaphragm) and the stimulating effect of insulin on this process have been extensively studied (reviews 3, 4), very little is known concerning carbohydrate metabolism of adipose tissue. Krahl (3) reported that rat adipose tissue utilizes glucose in vitro and that this utilization is also stimulated by insulin. Furthermore, insulin enhances glycogen deposition in adipose tissue in vivo (5, 6, 7, 8). Fawcet (9) concluded that insulin in vivo has a direct local action on the adipose tissue at the site of injection. The nutritional state of the animal seems to play an important role in regulating the metabolic activities of adipose tissue.