DNA Sequence of a Gene Encoding a BALB/c Mouse L d Transplantation Antigen

作者：Kevin W. Moore, Beverly Taylor Sher, Yi Sun, Kurt A. Eakle, Leroy Hood · 发表于：Science · 年份：1982 · DOI：10.1126/science.7058332 · 被引用次数：192 · 研究领域：Virus-based gene therapy research、RNA Interference and Gene Delivery、Viral Infectious Diseases and Gene Expression in Insects

The sequence of a gene, denoted 27.5, encoding a transplantation antigen for the BALB/c mouse has been determined. Gene transfer studies and comparison of the translated sequence with the partial amino acid sequence of the Ld transplantation antigen establish that gene 27.5 encodes an Ld polypeptide. A comparison of the gene 27.5 sequence with several complementary DNA sequences suggests that the BALB/c mouse may contain a number of closely related L-like genes. Gene 27.5 has eight exons that correlate with the structural domains of the transplantation antigen.