Inhibitory receptors abound?

作者：John C. Cambier · 发表于：Proceedings of the National Academy of Sciences · 年份：1997 · DOI：10.1073/pnas.94.12.5993 · 被引用次数：103 · 研究领域：Receptor Mechanisms and Signaling、Monoclonal and Polyclonal Antibodies Research、Bioactive Compounds and Antitumor Agents

Receptor biologists have traditionally focused on receptors that are physiologically coupled to inductive responses such as gene expression, cytokinesis, secretion, or entry into the cell cycle. It has generally been assumed that such inductive responses were terminated by ligand decay or receptor desensitization, which lead to cessation of signaling. While such mechanisms are clearly operative, a number of recent experiments have demonstrated that inhibitory receptors exist that function to attenuate inductive signals and further indicate that these receptors play a very important regulatory role in biology. Relatively few inhibitory receptors have been defined in part because the effects of these receptors can only be detected against the backdrop of an inductive signal. However, this situation is rapidly changing as recent pioneering studies have provided new approaches to isolation of such receptors. Three reports published in recent months (1–3), one by Kubagawa et al. in the Proceedings (1), have identified two new extended families of cell surface proteins that may function as inhibitory receptors. These findings are discussed below in the context of known inhibitory receptors and their mode of action (Table 1).