Genome sequence and analysis of the tuber crop potato

作者：X X Xu, Pan S, Shifeng Cheng, Bo Zhang, Mu D, Ni P, Gengyun Zhang, F. Guzmán, Michael Torres, Roberto Lozano, Olga Ponce, Diana Martinez, Germán De la Cruz, Virupaksh U. Patil, Б. Б. Кузнецов, Nikolai V. Ravin, Tatjana V. Kolganova, Alexey V. Beletsky, Andrei V. Mardanov, Alex Di Genova, Bolser Dc, Guangcun Li, Yu Yang, Hanhui Kuang, Qun Hu, Xingyao Xiong, Gerard J. Bishop, Nilo Mejía, Robert Gromadka, Jan Gawor, Paweł Szczęsny, Zhonghua Zhang, C Liang, Jun He, Ying Li, Y U E J I He, Jianfei Xu, Youjun Zhang, Binyan Xie, Yongchen Du, Merideth Bonierbale, Marc Ghislain, María del Rosario Herrera, Marco Pietrella, Gaetano Perrotta, Paolo Facella, Kimberly O’Brien, L López Barreiro, Gabriela A. Massa, Luis Diambra, Brett R. Whitty, Brieanne Vaillancourt, Haining Lin, Alicia N. Massa, Michael Geoffroy, Steven Lundback, Dean DellaPenna, Sanjeev Kumar Sharma, David Marshall, Robbie Waugh, Marialaura Destefanis, István Nagy, Susan Thomson, Mark Fiers, Mads Sønderkær, Marina Iovene, Giovana A. Torres, Richard E. Veilleux, Jan de Boer, Theo Borm, Bjorn Kloosterman, Herman van Eck, Richard G. F. Visser, Erwin Datema, Bas te Lintel Hekkert, Roeland C. H. J. van Ham, Aska Goverse · 发表于：Nature · 年份：2011 · DOI：10.1038/nature10158 · 被引用次数：2132 · 研究领域：Plant Pathogens and Resistance、Plant Disease Resistance and Genetics、Potato Plant Research

Potato (Solanum tuberosum L.) is the world’s most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop. The genome of the potato (Solanum tuberosum L.), a staple crop vital to food security, has been sequenced. The Potato Genome Sequencing Consortium sequenced a homozygous doubled-monoploid potato clone as well as a heterozygous diploid clone. Genome analysis reveals traces of at least two genome duplication events and genes specific to Asterids, a large clade of flowering plants of which the potato is the first to be sequenced. Gene presence/absence variants...