Localization of C‐reactive protein in synovium of patients with rheumatoid arthritis

作者：Jonathan D. Gitlin, Joan I Gitlin, David F. Gitlin · 发表于：Arthritis & Rheumatism · 年份：1977 · 被引用次数：86 · 研究领域：Streptococcal Infections and Treatments、Musculoskeletal synovial abnormalities and treatments、Toxin Mechanisms and Immunotoxins

Synovial biopsies from 8 patients with rheumatoid arthritis, 2 patients with degenerative osteoarthritis, and 4 patients with nonarthritic disease were studied for localization of C-reactive protein (CRP) using immunofluorescence microscopy. The nuclei of many synoviocytes and histiocytes in rheumatoid synovial membrane were found to bind CRP. Cultures of rheumatoid synovium in 14C-labeled amino acids produced radioactive IgG, IgM, IgA, and C3; but not CRP, indicating the synovial-bound CRP was not of local origin. A few CRP-binding nuclei were present in one osteoarthritis synovium, but none was found in the other and none in synovium from the 4 nonarthritis patients. The nature of the nuclear CRP ligand in rheumatoid synovium was not determined.