A Solution to the 2-Pyridyl Organometallic Cross-Coupling Problem: Regioselective Catalytic Direct Arylation of Pyridine N-Oxides

作者：Louis‐Charles Campeau, Sophie A. L. Rousseaux, Keith Fagnou · 发表于：Journal of the American Chemical Society · 年份：2005 · DOI：10.1021/ja056800x · 被引用次数：538 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Coordination Chemistry and Organometallics

Direct arylation reactions of pyridine N-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridine N-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions.