A new principle of RNA folding based on pseudoknotting

作者：Cornelis W.A. Pleij, Krijn Rietveld, Leendert Bosch · 发表于：Nucleic Acids Research · 年份：1985 · DOI：10.1093/nar/13.5.1717 · 被引用次数：424 · 研究领域：RNA and protein synthesis mechanisms、RNA modifications and cancer、RNA Research and Splicing

Tertiary interactions involving hairpin or interior loops of RNA can lead to extended quasi-continuous double helical stem regions, consisting of coaxially stacked segments of duplex RNA, bridged by single-stranded connections. This type of compact folding plays a role in various strategic regions of RNA molecules. Their role in ribosome functioning, RNA splicing and recognition of tRNA-like structures is discussed.