Some aspects of the mode of action of chlorhexidine

作者：W. B. Hugo, A R Longworth · 发表于：Journal of Pharmacy and Pharmacology · 年份：1964 · DOI：10.1111/j.2042-7158.1964.tb07384.x · 被引用次数：323 · 研究领域：Antimicrobial agents and applications、Photodynamic Therapy Research Studies、Phenothiazines and Benzothiazines Synthesis and Activities

Abstract Chlorhexidine is rapidly adsorbed by bacterial cells and this adsorption is accompanied by other cytological changes which include changes in the permeability of the cells and in their optical properties. The amount of drug adsorption causing maximum leakage of cell constituents and changes in extinction was found to be equivalent for Escherichia coli and for Staphylococcus aureus. Higher doses of chlorhexidine causing a higher level of drug adsorption caused correspondingly less leakage and change in extinction although such higher doses were more rapidly bactericidal.