Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion

作者：Makiko Yamamoto, Ajit K. Bharti, Yongqing Li, Donald W. Kufe · 发表于：Journal of Biological Chemistry · 年份：1997 · DOI：10.1074/jbc.272.19.12492 · 被引用次数：308 · 研究领域：Glycosylation and Glycoproteins Research、Galectins and Cancer Biology、Monoclonal and Polyclonal Antibodies Research

The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta-catenin. Similar findings have been obtained for gamma-catenin but not alpha-catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL site that is responsible for direct binding to beta-catenin. The results further demonstrate that interaction of DF3 and beta-catenin is dependent on cell adhesion. These findings and the role of beta-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.