Inhibition of NF-κB by Sodium Salicylate and Aspirin

作者：Elizabeth B. Kopp, Sankar Ghosh · 发表于：Science · 年份：1994 · DOI：10.1126/science.8052854 · 被引用次数：1761 · 研究领域：NF-κB Signaling Pathways、Immune Response and Inflammation、Cytokine Signaling Pathways and Interactions

The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.