Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

作者：Bihui H. Ye, Florigio Lista, Francesco Lo‐Coco, Daniel M. Knowles, Kenneth Offit, Raju S. K. Chaganti, Riccardo Dalla‐Favera · 发表于：Science · 年份：1993 · DOI：10.1126/science.8235596 · 被引用次数：694 · 研究领域：Lymphoma Diagnosis and Treatment、Retinoids in leukemia and cellular processes、CNS Lymphoma Diagnosis and Treatment

The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.