Interleukin‐1β+3953 allele 2: association with disease status in adult periodontitis

作者：Elizabeth A. Gore, John J. Sanders, Janardan P. Pandey, Yuko Y. Palesch, G.M.P. Galbraith · 发表于：Journal Of Clinical Periodontology · 年份：1998 · DOI：10.1111/j.1600-051x.1998.tb02370.x · 被引用次数：219 · 研究领域：Oral microbiology and periodontitis research、Streptococcal Infections and Treatments、Immune Response and Inflammation

Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. The pro-inflammatory and bone resorptive properties of interleukin-1 beta (IL-1beta) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. In the study reported here, the frequency of IL-1beta genotypes including allele 2 of the IL-1beta+3953 restriction fragment length bi-allelic polymorphism was significantly increased in patients with advanced adult periodontitis compared to those with early and moderate disease. Furthermore, allele 2 was associated with increased production of IL-1beta by activated peripheral blood polymorphonuclear cells of patients with advanced disease, although this increase failed to reach statistical significance. Finally, the data obtained revealed significant linkage disequilibrium between allele 2 of the IL-1beta+3953 polymorphism and allele 2 of the bi-allelic IL-1alpha-889 polymorphism in both patients and orally healthy controls. These findings provide new insight into the possible role of IL-1alpha and beta gene polymorphisms in the susceptibility to adult periodontitis.