Antibiotic Selection Pressure and Resistance in Streptococcus pneumoniae and Streptococcus pyogenes

作者：Werner C. Albrich, Dominique L. Monnet, Stephan Harbarth · 发表于：Emerging infectious diseases · 年份：2004 · DOI：10.3201/eid1003.030252 · 被引用次数：370 · 研究领域：Pneumonia and Respiratory Infections、Antibiotic Use and Resistance、Bacterial Infections and Vaccines

We correlated outpatient antibiotic use with prevalence of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP), macrolide-resistant S. pneumoniae (MRSP), and macrolide-resistant S. pyogenes (MRGAS) in 20 countries. Total antibiotic use was correlated with PNSP (r = 0.75; p < 0.001), as was macrolide use with MRSP (r = 0.88; p < 0.001) and MRGAS (r = 0.71; p = 0.004). Streptococcal resistance is directly associated with antibiotic selection pressure on a national level.