Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

作者：Matthias W. Hentze, Sarah A. Keim, Panteleimon Papadopoulos, Stephen J. O’Brien, W.S. Modi, JamesW. Drysdale, Warren J. Leonard, Joe B. Harford, Richard D. Klausner · 发表于：Proceedings of the National Academy of Sciences · 年份：1986 · DOI：10.1073/pnas.83.19.7226 · 被引用次数：83 · 研究领域：RNA modifications and cancer、Molecular Biology Techniques and Applications、RNA and protein synthesis mechanisms

A genomic phage clone containing a full-length copy of a functional human gene for ferritin heavy chain has been isolated. The gene consists of four exons spanning approximately 3 kilobases and has been localized to chromosome 11. The functionality of the gene was demonstrated by the fact that both transient transfectants and stable transformants of murine fibroblasts actively transcribe human ferritin heavy-chain mRNA.