Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

作者：Frank J. Rauscher, Donna Cohén, Tom Curran, Timothy J. Bos, Peter K. Vogt, Dirk Bohmann, Robert Tjian, B. Robert Franza · 发表于：Science · 年份：1988 · DOI：10.1126/science.3130660 · 被引用次数：644 · 研究领域：Ubiquitin and proteasome pathways、interferon and immune responses、Immune Cell Function and Interaction

The Fos protein complex and several Fos-related antigens (FRA) bind specifically to a sequence element referred to as the HeLa cell activator protein 1 (AP-1) binding site. A combination of structural and immunological comparisons has identified the Fos-associated protein (p39) as the protein product of the jun proto-oncogene (c-Jun). The p39/Jun protein is one of the major polypeptides identified in AP-1 oligonucleotide affinity chromatography extracts of cellular proteins. These preparations of AP-1 also contain Fos and several FRA's. Some of these proteins bind to the AP-1 site directly whereas others, like Fos, appear to bind indirectly via protein-protein interactions. Cell-surface stimulation results in an increase in c-fos and c-jun products. Thus, the products of two protooncogenes (and several related proteins), induced by extracellular stimuli, form a complex that associates with transcriptional control elements containing AP-1 sites, thereby potentially mediating the long-term responses to signals that regulate growth control and development.