The change in properties of the stratum corneum as a function of depth

作者：C. S. King, S. P. Barton, Stephen C. Nicholls, Ronald Marks · 发表于：British Journal of Dermatology · 年份：1979 · DOI：10.1111/j.1365-2133.1979.tb05556.x · 被引用次数：83 · 研究领域：Advancements in Transdermal Drug Delivery、Ocular Surface and Contact Lens、Surfactants and Colloidal Systems

The constancy of stratum corneum thickness suggests an ordered decrease in intracorneal cohesion binding forces. In this study, intracorneal cohesion was measured in the vertical dimension by cohesography and the number of cells released after applying a standardized stimulus was determined before and after repeated stripping of the same sites with adhesive tape. In addition, surface replicas and the corneocytes from different levels were examined by scanning and transmission electron microscopy and differential phase interference microscopy. The results indicate a gradual loss of cohesion within the stratum corneum towards the surface and that anatomical changes take place in the corneocytes as they progress towards the surface.