Structure of the Receptor for Insulin-Like Growth Factor II: The Puzzle Amplified

作者：Richard A. Roth · 发表于：Science · 年份：1988 · DOI：10.1126/science.2964085 · 被引用次数：209 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Metabolism, Diabetes, and Cancer、Pancreatic function and diabetes

The insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural homologies to insulin and insulin-like growth factor I (IGF-I). In contrast to these other hormones, the in vivo function of IGF-II is not known. Although IGF-II can stimulate a broad range of biological responses in isolated cells, these responses have usually been found to be mediated by the insulin and IGF-I receptors. Recently, the receptor for IGF-II was found to also be the receptor for mannose-6-phosphate. Since this latter receptor has been implicated in targeting of lysosomal enzymes, the question is now raised of whether the same protein can also mediate metabolic responses to IGF-II.