Cytological aspects of the mode of action of chlorhexidine diacetate

作者：W. B. Hugo, A R Longworth · 发表于：Journal of Pharmacy and Pharmacology · 年份：1965 · DOI：10.1111/j.2042-7158.1965.tb07562.x · 被引用次数：90 · 研究领域：Pharmaceutical and Antibiotic Environmental Impacts、Antibiotic Resistance in Bacteria、Antimicrobial agents and applications

Abstract Electron microscopic examination of ultra-thin sections of Escherichia coli cells treated with various concentrations of chlorhexidine diacetate reveal two effects. In low drug concentrations many cells lose electron dense material leaving behind empty shells, in higher concentrations the appearance of the cytoplasm is significantly affected. These results are discussed in the light of biochemical findings under identical conditions.