Direct Intramolecular Conjugate Addition of Simple Alkenes to α,β-Unsaturated Carbonyls Catalyzed by Cu(OTf)2

作者：Yan Qin, Jian Lv, Sanzhong Luo, Jin‐Pei Cheng · 发表于：Organic Letters · 年份：2014 · DOI：10.1021/ol502373u · 被引用次数：30 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Synthesis and Catalysis、Synthesis and Catalytic Reactions

An unprecedented intramolecular conjugate addition of simple alkenes to α,β-unsaturated carbonyl compounds has been developed. A simple Lewis acid such as Cu(OTf)2 was found to effectively catalyze the reaction, and six- and five-membered cyclic products were obtained in moderate to high yields.