Three Hypolipidemic Drugs Increase Hepatic Palmitoyl-Coenzyme A Oxidation in the Rat

作者：Paul B. Lazarow · 发表于：Science · 年份：1977 · DOI：10.1126/science.195342 · 被引用次数：261 · 研究领域：Drug-Induced Hepatotoxicity and Protection、Metabolism and Genetic Disorders、Pharmacogenetics and Drug Metabolism

Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum.