Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study

作者：Pedro J. Ruiz, Juan Carlos Martínez‐Castrillo, Araceli Alonso Cánovas, Antonio Herranz Bárcenas, Lydia Vela, Pilar Sánchez Alonso, M. Mata, N. Olmedilla Gonzalez, Ignacio Mahíllo · 发表于：Journal of Neurology Neurosurgery & Psychiatry · 年份：2014 · DOI：10.1136/jnnp-2013-306787 · 被引用次数：254 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neurological disorders and treatments、Parkinson's Disease and Spinal Disorders

BACKGROUND: Impulse control disorders (ICDs) encompass a wide spectrum of abnormal behaviour frequently found in cases of Parkinson's disease (PD) treated with dopamine agonists (DAs). The main aim of this study was to analyse ICD prevalence with different DAs. METHODS: We carried out a multicentre transversal study to evaluate the presence of ICDs in patients with PD chronically treated (>6 months) with a single non-ergolinic DA (pramipexole, ropinirole, or rotigotine). Clinical assessment of ICD was performed using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's disease. RESULTS: Thirty-nine per cent of patients (91/233) fulfilled the clinical criteria for ICD. The group of patients with ICD symptoms (ICD+) differed from those without ICD symptoms (ICD-) in younger age and type of DA intake. Oral DA treatment (pramipexole and ropinirole) was associated with higher risk of ICDs compared with transdermal DA (rotigotine): 84/197 (42%) patients treated with oral DA developed ICD, versus 7/36 (19%) patients treated with transdermal DA (Fisher's exact text <0.01). In univariate analysis, a younger age (p<0.01), treatment with rasagiline (p<0.05), and especially treatment with an oral DA (pramipexole or ropinirole) (p<0.01) were significantly associated with ICD. Multivariate analysis confirmed that oral DA remained significantly associated with ICD (p: 0.014, OR: 3.14; 1.26-7.83). CONCLUSIONS: ICD was significantly associated with the use of the non-ergolinic ...