Aberrant Expression of Osteopontin and E-Cadherin Indicates Radiation Resistance and Poor Prognosis for Patients with Cervical Carcinoma

作者：Xinqiong Huang, Yujie Qian, Hainan Wu, Xiaoxue Xie, Qin Zhou, Ying Wang, Weilu Kuang, Lin Shen, Kai Li, Juan Su, Liangfang Shen, Xiang Chen · 发表于：Journal of Histochemistry & Cytochemistry · 年份：2014 · DOI：10.1369/0022155414561329 · 被引用次数：26 · 研究领域：Cancer Cells and Metastasis、Bone and Dental Protein Studies、Oral and Maxillofacial Pathology

Radiotherapy is the first-line treatment for all stages of cervical cancer, whether it is used for radical or palliative therapy. However, radioresistance of cervical cancer remains a major therapeutic problem. Consequently, we explored if E-cadherin (a marker of epithelial-mesenchymal transition) and osteopontin could predict radioresistance in patients with locally advanced cervical squamous cell carcinoma (LACSCC). Patients were retrospectively reviewed and 111 patients divided into two groups (radiation-resistant and radiation-sensitive groups) according to progression-free survival (PFS). In pretreated paraffin-embedded tissues, we evaluated E-cadherin and osteopontin expression using immunohistochemical staining. The percentage of patients with high osteopontin but low E-cadherin expression in the radiation-resistant group was significantly higher than those in the radiation-sensitive group (p<0.001). These patients also had a lower 5-year PFS rate (p<0.001). Our research suggests that high osteopontin but low E-cadherin expression can be considered as a negative, independent prognostic factor in patients with LACSCC ([Hazard ratios (95% CI) 6.766 (2.940, 15.572)], p<0.001).