TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

作者：Hiroshi Shibuyà, Toshihiro Yamaguchi, Kyoko Shirakabe, Akane Tonegawa, Yukiko Gotoh, Naoto Ueno, Kenji Irie, Eisuke Nishida, Kunihiro Matsumoto · 发表于：Science · 年份：1996 · DOI：10.1126/science.272.5265.1179 · 被引用次数：586 · 研究领域：TGF-β signaling in diseases、NF-κB Signaling Pathways、Cell Adhesion Molecules Research

Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction.