A DNA Nanostructure‐based Biomolecular Probe Carrier Platform for Electrochemical Biosensing

作者：Hao Pei, Na Lü, Yanli Wen, Shiping Song, Yan Liu, Hao Yan, Chunhai Fan · 发表于：Advanced Materials · 年份：2010 · DOI：10.1002/adma.201002767 · 被引用次数：564 · 研究领域：Advanced biosensing and bioanalysis techniques、RNA and protein synthesis mechanisms、DNA and Nucleic Acid Chemistry

A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.