Enantioselective Allylic Amination of Morita–Baylis–Hillman Carbonates Catalysed by Modified Cinchona Alkaloids

作者：Shanjun Zhang, Hai‐Lei Cui, Kun Jiang, Rui Li, Zhenyu Ding, Ying‐Chun Chen · 发表于：European Journal of Organic Chemistry · 年份：2009 · DOI：10.1002/ejoc.200900944 · 被引用次数：54 · 研究领域：Asymmetric Synthesis and Catalysis、Chemical Synthesis and Analysis、Advanced Synthetic Organic Chemistry

Abstract An efficient procedure for the asymmetric allylic amination of Morita–Baylis–Hillman carbonates with cyclic imides catalysed by commercially available cinchona alkaloids is reported. It proves to be a facile protocol that affords α‐methylene β‐amino esters with good‐to‐excellent enantioselectivities (up to 94 % ee ) and in high yields (up to 97 %). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)