Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability

作者：Michael S. Malamas, Albert J. Robichaud, Jim Erdei, Dominick Quagliato, William R. Solvibile, Ping Zhou, Koi Morris, Jim Turner, Erik Wagner, Kristi Fan, Andrea Olland, Steve Jacobsen, Peter H. Reinhart, David Riddell, Menelas N. Pangalos · 发表于：Bioorganic & Medicinal Chemistry Letters · 年份：2010 · DOI：10.1016/j.bmcl.2010.09.029 · 被引用次数：52 · 研究领域：Drug Transport and Resistance Mechanisms、Protein Structure and Dynamics、Protein Interaction Studies and Fluorescence Analysis