Oseltamivir Treatment for Influenza in Hospitalized Children Without Underlying Diseases

作者：Mercedes Bueno, Cristina Calvo, Ana María Méndez-Echevarría, María Isabel de José, Mar Santos, Jaime Carrasco, Miriann Tovizi, Sara Guillén, Ana D´Ors de Blas, Marta Llorente, Alfredo Tarrago, Luis Escosa, María José Cilleruelo, Cristina Tomatis, Daniel Blazquez, Enrique Otheo, Diana Mazagatos, María Luz García‐García · 发表于：The Pediatric Infectious Disease Journal · 年份：2013 · DOI：10.1097/inf.0b013e31829be4bc · 被引用次数：24 · 研究领域：Influenza Virus Research Studies、Respiratory viral infections research、Pneumonia and Respiratory Infections

AIM: To determine whether the treatment with oseltamivir improves the outcome of children with confirmed influenza infection and no other underlying disease. METHODS: Multicentric, retrospective study performed in 10 hospitals of Madrid between September 2010 and June 2012. All children admitted to the hospitals with confirmed influenza infections were eligible. Children with risk factors for serious disease and nosocomial influenza infections were excluded. Asthma was not considered an exclusion factor. The study compared patients treated and untreated with oseltamivir. Fever duration, oxygen support, antibiotics administration, length of hospital stay, intensive care admission and bacterial complications were analyzed. To compare variables, χ(2) test, Fisher exact test, ANOVA or Mann-Whitney U test were used. RESULTS: Two hundred eighty-seven children were included and 93 of them were treated with oseltamivir (32%). There were no significant differences between treated and untreated patients in days of fever after admission (1.7 ± 2; 2.1 ± 2.9, P > 0.05), length of stay (5.2 ± 3.6; 5.5 ± 3.4, P > 0.05), days of hypoxia (1.6 ± 2.3; 2.1 ± 2.9, P > 0.05), diagnosis of bacterial pneumonia (10%; 17%, P > 0.05), intensive care admission (6.5%; 1.5%,P > 0.05) or antibiotic prescription (44%; 51%, P > 0.05). There were no differences when the population was stratified by age (below or over 1 year) or by the presence or absence of asthma. CONCLUSIONS: There were no proven benefits o...