Parameters Driving the Selection of Nelfinavir-Resistant Human Immunodeficiency Virus Type 1 Variants

作者：Virginie Perrin, Fabrizio Mammano · 发表于：Journal of Virology · 年份：2003 · DOI：10.1128/jvi.77.18.10172-10175.2003 · 被引用次数：35 · 研究领域：HIV Research and Treatment、HIV/AIDS drug development and treatment、Hepatitis C virus research

We investigated the parameters driving nelfinavir resistance, along the D30N and L90M evolutionary pathways. The advantage of the D30N mutant was mostly due to its resistance level, while the L90M mutation allowed preservation of infectivity coupled with minimal resistance. Emergence of secondary mutations further increased the selective advantage of viruses harboring D30N.