Colony formation by primitive haemopoietic progenitors in cocultures of bone marrow cells and stromal cells

作者：M. Y. Gordon, Jill A. Hibbin, Lyndal U. Kearney, E. C. Gordon‐Smith, John M. Goldman · 发表于：British Journal of Haematology · 年份：1985 · DOI：10.1111/j.1365-2141.1985.tb07393.x · 被引用次数：68 · 研究领域：Hematopoietic Stem Cell Transplantation、Immunotherapy and Immune Responses、T-cell and B-cell Immunology

Human bone marrow contains a class of human haemopoietic progenitor cells that adhere to cultured marrow stromal cells and form colonies of blast cells. These progenitor cells are found in the non-adherent mononuclear fraction of normal human bone marrow. They are not in active cell cycle and do not express Ia-like (HLA-DR) antigens but appear to be capable of self-renewal in vitro. These properties indicate that they should be classified as members of the primitive haemopoietic progenitor cell compartment.