Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension

作者：Carmine Savoia, Lidia Sada, Luigi Zezza, Lorenzo Pucci, Francesco Maria Lauri, Alberto Befani, Alessandro Alonzo, Massimo Volpe · 发表于：International Journal of Hypertension · 年份：2011 · DOI：10.4061/2011/281240 · 被引用次数：159 · 研究领域：Sodium Intake and Health、Blood Pressure and Hypertension Studies、Hormonal Regulation and Hypertension

Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.