Alkyl−Alkyl Suzuki Cross-Couplings of Unactivated Secondary Alkyl Halides at Room Temperature

作者：Bunnai Saito, Gregory C. Fu · 发表于：Journal of the American Chemical Society · 年份：2007 · DOI：10.1021/ja074008l · 被引用次数：267 · 研究领域：Catalytic Cross-Coupling Reactions、Chemical synthesis and alkaloids、Radical Photochemical Reactions

A commercially available 1,2-diamine serves as an effective ligand for metal-catalyzed cross-couplings of unactivated alkyl electrophiles at room temperature. In particular, Ni/ trans - N,N ‘-dimethyl-1,2-cyclohexanediamine provides the first method for achieving alkyl−alkyl Suzuki reactions of unactivated secondary alkyl halides with alkylboranes; earlier success in Suzuki couplings of such electrophiles had been restricted to reactions with aryl- and vinylboron reagents at elevated temperature.