The Toll-receptor family and control of innate immunity

作者：Elizabeth B. Kopp, Ruslan M. Medzhitov · 发表于：Current Opinion in Immunology · 年份：1999 · DOI：10.1016/s0952-7915(99)80003-x · 被引用次数：657 · 研究领域：Immune Response and Inflammation、Antimicrobial Peptides and Activities、Invertebrate Immune Response Mechanisms

Innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants.