Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

作者：M. Ángela Nieto, Michael G. Sargent, David G. Wilkinson, Jonathan Cooke · 发表于：Science · 年份：1994 · DOI：10.1126/science.7513443 · 被引用次数：764 · 研究领域：Cancer-related gene regulation、Congenital heart defects research、Epigenetics and DNA Methylation

Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick embryos were incubated with antisense oligonucleotides to chick Slug. These oligonucleotides specifically inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed. This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube.