Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults

作者：Ole Østerberg, Radojka M. Savić, Mats O. Karlsson, Ulrika S. H. Simonsson, Jens Peter Nørgaard, Johan Vande Walle, Henrik Agersø · 发表于：The Journal of Clinical Pharmacology · 年份：2006 · DOI：10.1177/0091270006291838 · 被引用次数：59 · 研究领域：Pharmaceutical studies and practices、Urinary Bladder and Prostate Research、Drug Solubulity and Delivery Systems

The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.