Disseminated Infection with Balamuthia mandrillaris in a Dog

作者：Oded Foreman, Jane E. Sykes, Louise M. Ball, Ning Yang, H. De Cock · 发表于：Veterinary Pathology · 年份：2004 · DOI：10.1354/vp.41-5-506 · 被引用次数：55 · 研究领域：Legionella and Acanthamoeba research、Vibrio bacteria research studies、Bacterial biofilms and quorum sensing

Bilateral chronic granulomatous nephritis and meningoencephalitis were diagnosed on necropsy of a 2-year-old male Great Dane dog. The causative agent was identified as Balamuthia mandrillaris, based on morphologic features, immunohistochemical staining, and deoxyribonucleic acid detection using the polymerase chain reaction with newly designed primer pairs. Trophozoite and cystic forms of the amoeba were evident within the kidneys and brain parenchyma. This is the first report on a B. mandrillaris infection in a dog.