Mass Spectrometric Analysis of the Schistosoma m ansoni Tegumental Sub-proteome

作者：Bas W. M. van Balkom, Renske A. van Gestel, Jos F.H.M. Brouwers, Jeroen Krijgsveld, Aloysius G. M. Tielens, Albert J. R. Heck, Jaap J. van Hellemond · 发表于：Journal of Proteome Research · 年份：2005 · DOI：10.1021/pr050036w · 被引用次数：166 · 研究领域：Parasites and Host Interactions、Trace Elements in Health、Biochemical and Molecular Research

Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival.