Functions of netrins and semaphorins in axon guidance

作者：Joseph G. Culotti, Alex L. Kolodkin · 发表于：Current Opinion in Neurobiology · 年份：1996 · DOI：10.1016/s0959-4388(96)80012-2 · 被引用次数：139 · 研究领域：Axon Guidance and Neuronal Signaling、Apelin-related biomedical research、Neuroscience, Education and Cognitive Function

Neuronal growth cones respond to both contact-mediated and chemotropic guidance cues; these cues can be either attractive or repulsive. This past year has seen further characterization of two gene families implicated in long-range chemoattraction and chemorepulsion: the netrins and the semaphorins. Analysis of invertebrate members of these gene families demonstrates in vivo how netrins play multiple roles in axonal guidance in Caenorhabditis elegans, how specific domains of the netrin molecule confer attractive and repulsive guidance cues, and how semaphorins can function to generate neuromuscular specificity.