Models for Evaluating Agents Intended for the Prophylaxis, Mitigation and Treatment of Radiation Injuries Report of an NCI Workshop, December 3–4, 2003

作者：Helen B. Stone, John E. Moulder, C. Norman Coleman, K. Kian Ang, Mitchell Steven Anscher, Mary Helen Barcellos‐Hoff, William S. Dynan, John R. Fike, David J. Grdina, Joel S. Greenberger, Martin Hauer‐Jensen, Richard Peter Hill, Richard N. Kolesnick, Thomas J. MacVittie, Cheryl L. Marks, William H. McBride, Noelle F. Metting, Terry C. Pellmar, Mary E. Purucker, Mike E. C. Robbins, Robert H. Schiestl, Thomas M. Seed, Joseph E. Tomaszewski, Elizabeth L. Travis, Paul E. Wallner, Mary K. Wolpert, Daniel W. Zaharevitz · 发表于：Radiation Research · 年份：2004 · DOI：10.1667/rr3276 · 被引用次数：245 · 研究领域：Effects of Radiation Exposure、Radiation Therapy and Dosimetry、Ultrasound and Hyperthermia Applications

Stone, H. B., Moulder, J. E., Coleman, C. N., Ang, K. K., Anscher, M. S., Barcellos-Hoff, M. H., Dynan, W. S., Fike, J. R., Grdina, D. J., Greenberger, J. S., Hauer-Jensen, M., Hill, R. P., Kolesnick, R. N., MacVittie, T. J., Marks, C., McBride, W. H., Metting, N., Pellmar, T., Purucker, M., Robbins, M. E., Schiestl, R. H., Seed, T. M., Tomaszewski, J., Travis, E. L., Wallner, P. E., Wolpert, M. and Zaharevitz, D. Models for Evaluating Agents Intended for the Prophylaxis, Mitigation and Treatment of Radiation Injuries. Report of an NCI Workshop, December 3–4, 2003. Radiat. Res. 162, 711–728 (2004).To develop approaches to prophylaxis/protection, mitigation and treatment of radiation injuries, appropriate models are needed that integrate the complex events that occur in the radiation-exposed organism. While the spectrum of agents in clinical use or preclinical development is limited, new research findings promise improvements in survival after whole-body irradiation and reductions in the risk of adverse effects of radiotherapy. Approaches include agents that act on the initial radiochemical events, agents that prevent or reduce progression of radiation damage, and agents that facilitate recovery from radiation injuries. While the mechanisms of action for most of the agents with known efficacy are yet to be fully determined, many seem to be operating at the tissue, organ or whole animal level as well as the cellular level. Thus research on prophylaxis/protection, mitigation and...