Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords

作者：Zhigong Wang, Xiaosong Gu, Xiaoying Lü, Zheng‐Lin Jiang, Wenyuan Li, Guangming Lü, Yufeng Wang, Xiaoyan Shen, Xintai Zhao, Huiling Wang, Zhenyu Zhang, Hongmei Shen, Wu Yang, Weixing Shen, Jingyang Zhang, Dong Chen, Xiaoyi Mao, Shen Huaxiang · 发表于：Progress in Natural Science Materials International · 年份：2009 · DOI：10.1016/j.pnsc.2009.02.005 · 被引用次数：20 · 研究领域：Neuroscience and Neural Engineering、Photoreceptor and optogenetics research、Muscle activation and electromyography studies

Due to the difficulty in spinal cord regeneration with biological methods, the microelectronic neural bridge, a new concept based on microelectronic technology, is presented. The microelectronic system has been realized in the forms of hybrid and integrated circuits. The integrated circuits for neural signal detection, stimulation, and regeneration are realized in a CMOS process. In animal experiments with 100 toads, 48 rats, and 3 rabbits, nerve signals have been successfully detected from spinal cords and sciatic nerves, and functional electrical stimulation has been carried out for spinal cords and sciatic nerves. When the microelectronic system is bridged between the controlling and stimulated nerve, the relevant motion of legs and nerve signal waveforms, which are stimulated by the evoked or spontaneous nerve signal through such a system, have been observed. Therefore, the feasibility of the presented method was demonstrated.