1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D 3 in the Intestine

作者：Anthony W. Norman, James F. Myrtle, Ronald J. Miogett, Henry G. Nowicki, Vincent P. Williams, G. Popjaák · 发表于：Science · 年份：1971 · DOI：10.1126/science.173.3991.51 · 被引用次数：223 · 研究领域：Vitamin D Research Studies、Helicobacter pylori-related gastroenterology studies、Neuroendocrine Tumor Research Advances

The major polar metabolite of cholecalciferol (vitamin D(3)) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C(27)H(44)0(3) and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine.