Dying-back oligodendrogliopathy: A late sequel of myelin-associated glycoprotein deficiency

作者：Hans Lassmann, Udo Bartsch, Dirk Montag, Melitta Schachner · 发表于：Glia · 年份：1997 · DOI：10.1002/(sici)1098-1136(199702)19:2<104::aid-glia2>3.0.co;2-0 · 被引用次数：83 · 研究领域：Hereditary Neurological Disorders、Peripheral Neuropathies and Disorders、Neurogenesis and neuroplasticity mechanisms

Ultrastructural analysis of myelin from 8-month-old mice deficient in the myelin-associated glycoprotein revealed pronounced and characteristic alterations of the periaxonal oligodendrocyte processes, consisting of intracytoplasmic deposition of vesicular material, multivesicular bodies, mitochondria, and lipofuscin granules, as well as granular or paracrystalline inclusions. These alterations are similar to those described before as "dying-back oligodendrogliopathy" in diseases of toxic or immune-mediated demyelination including multiple sclerosis.