Energy Metabolism in Cardiac Remodeling and Heart Failure

作者：Paula S. Azevedo, Marcos Ferreira Minicucci, Dos Santos, Sérgio Alberto Rupp de Paiva, Leonardo Antônio Mamede Zornoff · 发表于：Cardiology in Review · 年份：2012 · DOI：10.1097/crd.0b013e318274956d · 被引用次数：106 · 研究领域：Cardiovascular Function and Risk Factors、Cardiac Valve Diseases and Treatments、Fuel Cells and Related Materials

Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal conditions. During heart remodeling, however, the fuel preference switches to glucose. In the earlier stages of cardiac remodeling, changes in energy metabolism are considered crucial to protect the heart from irreversible damage. Furthermore, low fatty acid oxidation and the stimulus for glycolytic pathway lead to lipotoxicity, acidosis, and low adenosine triphosphate production. While myocardial function is directly associated with energy metabolism, the metabolic pathways could be potential targets for therapy in heart failure.