Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

作者：Filip K. Świrski, Matthias Nahrendorf, Martin Etzrodt, Moritz Wildgruber, Virna Cortez‐Retamozo, Peter Panizzi, Jose‐Luiz Figueiredo, Rainer H. Köhler, Aleksey Chudnovskiy, Peter Waterman, Elena Aïkawa, Thorsten R. Mempel, Peter Libby, Ralph Weissleder, Mikaël J. Pittet · 发表于：Science · 年份：2009 · DOI：10.1126/science.1175202 · 被引用次数：2214 · 研究领域：Immune Response and Inflammation、Immune cells in cancer、S100 Proteins and Annexins

A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase their motility, exit the spleen en masse, accumulate in injured tissue, and participate in wound healing. These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation.