HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

作者：Michael Emerman, Michael H. Malim · 发表于：Science · 年份：1998 · DOI：10.1126/science.280.5371.1880 · 被引用次数：386 · 研究领域：HIV Research and Treatment、HIV/AIDS drug development and treatment、RNA Interference and Gene Delivery

Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the intracellular trafficking of viral and host cell proteins. Detailed analysis of the interplay between these viral proteins and normal cellular activities has provided new insights into central questions of virology and host cell biology.