GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

作者：Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen, Matthew Liebers, Ved V. Topkar, Vishal Thapar, Nicolas Wyvekens, Cyd Khayter, A. John Iafrate, Long P. Le, Martin J. Aryee, J. Keith Joung · 发表于：Nature Biotechnology · 年份：2014 · DOI：10.1038/nbt.3117 · 被引用次数：2390 · 研究领域：CRISPR and Genetic Engineering、RNA regulation and disease、Advanced biosensing and bioanalysis techniques