Islet-Cell Antibodies and Beta-Cell Function in Monozygotic Triplets and Twins Initially Discordant for Type I Diabetes Mellitus

作者：Sathyanarayana Srikanta, Om P. Ganda, George S. Eisenbarth, J. Stuart Soeldner · 发表于：New England Journal of Medicine · 年份：1983 · DOI：10.1056/nejm198302103080607 · 被引用次数：224 · 研究领域：Pancreatic function and diabetes、Diabetes and associated disorders、Diabetes Management and Research

Type I diabetes mellitus has until recently been considered a disease that has an acute onset and is characterized by the sudden appearance of metabolic abnormalities in previously "healthy" people. Recent studies have suggested that there is a latent period before the development of overt diabetes, during which islet-cell antibodies arc present.1 2 3 4 In an ongoing prospective study of "genetic prediabetes," conducted by one of us (J.S.S.) and co-workers at the Joslin Diabetes Center, a set of monozygotic triplets5 and a set of monozygotic twins initially discordant for Type I diabetes were identified. These patients were unique in that their beta-cell . . .